When it comes to choosing the best joint pain supplement, it can be difficult because there are so many options.  The best advice is to look for ingredients that have been proven to improve painful joints and read reviews from joint pain sufferers like you.


Supplement NameActive IngredientsStated BenefitsQuantityPriceRating
Synotrex Glucosamine, Chondroitin, Turmeric, SAMe, MSM & vitamins A, C & E Improved strength and mobility 30 day supplyfree trial 4.7 out of 5 stars (65 customer reviews)

Dr. Miller's Joint Repair

Glucosamine & Chondroitin Sulfate, MSM, and a lot more Superior Blend of ingredients for maximum benefit 90 day supply$52.99 4.6 out of 5 stars (51 customer reviews)

Cosamin DS Joint Health Supplement

Only brand that contains pharmaceutical-grade TRH122 chondroitin sulfate and FCHG49 glucosamine that includes Vitamins B-1, B-2. B-6, B-12 and more, for enhanced absorption 40 day supply$62.99 4.6 out of 5 stars (159 customer reviews)

Schiff MegaRed Joint Care

MegaRed krill oil provides an optimal combination of omega-3 fatty acids, phospholipids and powerful antioxidants including astaxanthin to promote joint comfort* Starts Working in Less Than One Week** 110 day supply$52.99 4.4 out of 5 stars (84 customer reviews)

Osteo Bi-Flex Triple Strength

Glucosamine HCl 1,500 mg - Joint Shield Blend 1,288 mg (Chondroitin Sulfate, MSM, Collagen, Boswellia serrata, Hyaluronic Acid, 5-LOXIN Advanced AKBA) - Vitamin C 60 mg - Manganese 2 mg - Sodium 40 mg - Boron 3 mg Starts working to improve joint comfort within 7 days.* Triple strength joint supplement helps protect cartilage and helps with annoying flare-ups while renewing the cellular components within joints* 40 day supply$55.98 4.5 out of 5 stars (114 customer reviews)

Dr. David Williams' Joint Advantage Gold Joint Pain Relief Supplement

Natural eggshell membrane, glucosamine sulfate, bovine cartilege, and an exclusive mix of herbal extracts Stops joint pain quickly and helps build worn-down and damaged joints 120 day supply$89.97 4.2 out of 5 stars (13 customer reviews)



This webpage contains links to external webpages. The publisher of this website may receive compensation through purchases from those websites.

According to the Nutrition Business Journal, in 2012, U.S. consumers spent $753 million on joint pain relief supplements. Most joint pain supplements contain a combination of glucosamine hydrochloride or glucosamine sulfate and chondroitin in the sulfate form. These are naturally occurring ingredients in our bodies and are found in and around the cartilage that protects our joints. Researchers have found that glucosamine and chondroitin act in concert to reduce pain in certain people with osteoarthritis, the degenerative joint disease that affects 27 million Americans by regenerating the cartilage that is eroded by the disease.

In a large, multicenter trial published in 2006, researchers found some evidence that glucosamine and chondroitin alleviated pain in patients with moderate to severe knee osteoarthritis, the most common type. But subsequent studies have not confirmed that finding. And treatment guidelines issued in May 2013 by the American Academy of Orthopaedic Surgeons don’t recommend glucosamine and chondroitin supplements for symptomatic OA in the knee joint, citing lack of efficacy. They made no statement regarding the continued use of glucosamine and chondroitin for other joints or for joint pain causes other than OA.

Glucosamine and chondroitin have shown a good safety record in studies of up to three years, but they may interact with some drugs, particularly blood thinners. So check with your doctor first if you take warfarin (Coumadin and generic) or another blood-thinning drug. At recommended daily doses, most provide about 1,500 milligrams of glucosamine salt and 1,200 milligrams of chondroitin sulfate. People who are allergic to shellfish should consider avoiding glucosamine derived from crustacean shells, a common source. Keep a daily pain diary to gauge whether the supplements are helping. If you’ve seen no improvement after three months, it’s unlikely that you will, our experts say.